skip to content
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets Preview this item
ClosePreview this item

Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets

Author: Urs A Boelsterli
Publisher: New York : Informa Healthcare, ©2009.
Edition/Format:   Print book : English : 2nd edView all editions and formats
Summary:
The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.
You are not connected to the UNCG University Libraries network. Access to online content and services may require you to authenticate with your library. UNCG Subscription Login
Getting this item's online copy... Getting this item's online copy...

Find a copy in the library

Getting this item's location and availability... Getting this item's location and availability...

WorldCat

Find it in libraries globally
Worldwide libraries own this item

Details

Document Type: Book
All Authors / Contributors: Urs A Boelsterli
ISBN: 9780849372728 0849372720
OCLC Number: 475581759
Notes: UNCG University Libraries notes:
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
Description: 399 pages : illustrations ; 25 cm
Contents: Introduction --
Types of toxic responses --
Organ-selective toxicity --
Cellular transport and selective accumulation of potentially toxic xenobiotics --
Bioactivation of xenobiotics to reactive metabolites --
Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation --
Disruption of cellular calcium homeostasis --
Mechanisms of necrotic and apoptotic cell death --
Impairment of cell proliferation and tissue repair --
Covalent binding of reactive metabolites to cellular macromolecules --
Immune mechanisms --
Cytokine-mediated toxicity --
Specific inactivation of enzymes and other proteins --
Interactions of xenobiotics with ion transporters --
Nuclear receptor-mediated toxicity --
Activation or disruption of cellular signal transduction by xenobiotics --
Disruption of mitochondrial function and mitochondria-mediated toxicity --
Novel mechanisms derived from systems toxicology.
Responsibility: Urs A. Boelsterli.
Local System Bib Number:
ocn475581759

Abstract:

Mechanistic Toxicology  Read more...
Retrieving notes about this item Retrieving notes about this item

Reviews

Editorial reviews

Publisher Synopsis

'Students taking formal training in toxicology would definitely benefit from adding this book to their collection, since it covers many recent advances in the field.' - British Toxicology Society Read more...

 
User-contributed reviews

Tags

Be the first.

Similar Items

Related Subjects:(1)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.